Hello from Florida,
I've used 2 different DB-9 to USB cables I bought at hamfests for a buck; downloaded the drivers, and had no trouble programming the scanners using ARC 780, Freescan, Proscan, ARC 996, and ARC 96.
Ensure you have the correct driver; you have selected the correct com port; ensure you have the software and the scanner both set to the same baud rate; and using the software, test the connection to the scanner before attempting database upload or download. These steps should solve the problem for you
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If you have come here to find out about the Uniden BC-780 you have come to the right place! In fact the discussion of the BC-780 is the only acceptable topic on this list. Please. I hope this is clear to all group members.